Granisetron primarily functions as a serotonin 5-HT3 receptor antagonist, exerting its antiemetic effects by blocking the action of serotonin at these receptors. By antagonizing the 5-HT3 receptors, granisetron inhibits serotonin-mediated signaling that contributes to nausea and vomiting. Unlike some other antiemetic drugs, granisetron does not directly affect dopamine receptors (as seen with dopamine receptor antagonists like metoclopramide) or muscarinic receptors (as seen with anticholinergic drugs like scopolamine). Its specificity for serotonin receptors makes it a valuable option for managing chemotherapy-
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment – Pharmacology and Mechanisms Natural products have long been vital in drug discovery due to their unique biocompatibility, novel structural backbones, and diverse pharmacological activities. Withaferin A isolated from Withania somnifera (L.) Dunal (WS), also kwon as Indian ginseng (Ashwagandha) and considered the king of Ayurvedic herbs has shown significant activity for various conditions., Please refer to 10.2147/DDDT.S422512 for more details., SPD Chemicals manufactures isolated Withaferin A (NLT-99 %),